Sentinel BioTherapeutics is a Houston-based clinical stage biotech company developing localized immunotherapies that safely activate the immune system against solid tumors.

Precision Immunomodulation for Durable Survival

Targeted Immune Activation in Difficult-to-Treat Locations

Our therapy delivers immune activating agents directly into anatomical spaces where cancer thrives and systemic drugs fail to reach in high doses— starting with the peritoneal and pleural cavities. This focused approach activates the local and systemic immune response for effective immunotherapy.

Enhancing Responsiveness to Immunotherapy

Priming the Adaptive Immune System for a More Complete Response

Our platform stimulates immune cells to express immune checkpoints, making more tumors responsive to effective immunotherapies. This approach holds promise for patients with limited options.

Fewer Side Effects, Better Living

More Immune Power, Less Collateral Damage

By acting locally at the disease site, our treatment reduces systemic exposure — limiting off-target toxicities and improving patient quality of life. Patients get a stronger immune response without the tradeoffs of conventional IL-2 therapy. (see Texas Monthly Magazine “Tiny Beads of Hope”)

For more information please contact us at [email protected]